Heptaminol hydrochloride (12 μL; 50% water/acetone) stimulates NO synthesis from constitutive NOS and attenuates TPA-induced depletion of NK cells at the edge of the mouse ear. Heptaminol hydrochloride exerts anti-proliferative and anti-inflammatory effects on TPA, suggesting important anti-tumor function[2].
| Animal Model: | Acute TPA-induced inflammatory ear skin changes in Balb/c mouse (5-7 wk)[2] |
| Dosage: | 2.5 nmol Heptaminol in 12 μL |
| Administration: | Topical treatment for single dose; Heptaminol was dissolved in 50% water/acetone; 30 min before 0.4 nmol TPA (in 12 μL acetone) treatment. |
| Result: | Stimulated NO production and directly inhibits tumors caused by TPA promoting inflammation.
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