4-Bromo-3-fluorotoluene

colorless to light yellow liqui

4-Bromo-3-fluorotoluene may be used in the preparation of 1-(4-cyano-3- fluorobenzyl)-5-imidazolecarboxaldehyde and 1-bromo-4-bromomethyl-2-fluorobenzene.

4-Bromo-3-fluorotoluene is used in the synthesis of S-trityl-L-cysteine based inhibitors that show potent antitumor activity in lung cancer models. Chemical reagent for organic synthesis.

4-Bromo-3-fluorotoluene (1-bromo-2-fluoro-4-methylbenzene) is an aryl fluorinated building block. Synthesis of 4-bromo-3-fluorotoluene from o-nitro-p-toluidine (Fast Red Base GL), via diazo reaction at high temperature, Sandmeyer reaction, reduction and Schiemann reaction has been reported. Its density and refractive index have been determined.

the preparation method of a 4-Bromo-3-fluorotoluene, it is characterized in that: 4-amino-3-toluene fluoride hydrobromate, Hydrogen bromide, water drips Sodium Nitrite/water down at-10-10 ℃ and carries out diazotization, reaction solution joins in cuprous bromide/hydrobromic solution, and bromination under the normal temperature was reacted 0.5-2 hour, separate, purifying obtains target product 4-Bromo-3-fluorotoluene.

[1] Method for preparing 4-bromine-3-fluorine methylbenzene. CN1274650C