Basic information Safety Related Supplier

SR-95531

Basic information Safety Related Supplier
SR-95531 Basic information
SR-95531 Chemical Properties
  • Melting point:200 °C(Solv: ethanol (64-17-5))
  • storage temp. Store at RT
  • solubility DMSO: 30 mg/mL
  • form solid
  • color white
Safety Information
  • WGK Germany 3
MSDS
SR-95531 Usage And Synthesis
  • DescriptionSR 95531 is a derivative of γ-aminobutyric acid (GABA) that acts as an antagonist of GABAA receptors (Ki = 74-150 nM). When administered intravenously, it elicits seizures in mice. SR 95531 differs in action from bicuculline (Item No. 11727) in that it antagonizes GABA-induced chloride currents but not those induced by pentobarbitone. It is effective against GABAA receptor isoforms from mice, rats, and humans.
  • UsesGabazine Hydrobromide is a specific GABA receptor antagonist. Does not affect GABA-transaminase or glutamate-decarboxylase activitites.
  • Biological ActivitySelective, competitive GABA A receptor antagonist. Displaces [ 3 H]-GABA from rat brain membranes with a K i of 150 nM. Unlike bicuculline, selectively antagonizes GABA-induced Cl - currents with little action on pentobarbitone-induced currents. Also acts as a low affinity glycine receptor antagonist.
  • Biochem/physiol ActionsSR-95531 is a specific GABAA receptor antagonist that does not affect GABA-transaminase or glutamate-decarboxylase activities.
SR-95531(104104-50-9)Related Product Information
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  • Company Name:J & K SCIENTIFIC LTD.
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