N-(5-benzyl-1,3-thiazol-2-yl)-2-(4,6-dimethylpyrimidin-2-yl)sulfanylacetamide

SirReal-1 is a potent and selective Sirt2 inhibitor（IC50 = 3.7 uM）[1].

SIRT2: 3.7 μM (IC₅₀)

[1] Schiedel M, Rumpf T, Karaman B, et al. Structure-Based Development of an Affinity Probe for Sirtuin2. Angew Chem Int Ed Engl. 2016;55(6):2252-2256. DOI:10.1002/anie.201509843
[2] Rumpf T, Schiedel M, Karaman B, et al. Selective Sirt2 inhibition by ligand-induced rearrangement of the active site.Nat Commun. 2015;6:6263. DOI:10.1038/ncomms7263