3,5-Bis(4-nitrophenoxy)benzoic acid

3,5-Bis(4-nitrophenoxy)benzoic acid is an inhibitor of γ-secretase. 3,5-Bis(4-nitrophenoxy)benzoic acid causes a decrease in the released levels of Aβ42 and notch-1 Aβ-like peptide 25 (Nβ25). 3,5-Bis(4-nitrophenoxy)benzoic acid, as a marker for fetal hypothyroidism, is a 3,3’-diiodothyronine sulfate (T2S) cross-reactive material in maternal serum[1].

ChEBI: 3,5-bis(4-nitrophenoxy)benzoic acid is an aromatic ether.

Inhibitor of γ -secretase; causes a decrease in the released levels of A β 42 and notch-1 A β -like peptide 25 (N β 25).

[1] Wu SY, et al. Compound W, a 3,3'-diiodothyronine sulfate cross-reactive substance in serum from pregnant women--a potential marker for fetal thyroid function. Pediatr Res. 2007;61(3):307-312. DOI:10.1203/pdr.0b013e318030d17d
[2] Ran Y, et al. Differential Inhibition of Signal Peptide Peptidase Family Members by Established γ-Secretase Inhibitors. PLoS One. 2015;10(6):e0128619. Published 2015 Jun 5. DOI:10.1371/journal.pone.0128619
[3] Greife A, et al. Canonical Notch signalling is inactive in urothelial carcinoma. BMC Cancer. 2014;14:628. Published 2014 Aug 29. DOI:10.1186/1471-2407-14-628