N-Benzyloleamide is a natural compound found in a variety of plants such as Tropaeolum tuberosum tubers and Lepidium meyenii (Maca). N-Benzyloleamide has been shown to have anti-inflammatory activity with IC50 values of 6.50±0.75 μM, 7.74±0.19 μM, and 8.37±0.09 μM in CCD-1109Sk, MRC-5, and RWPE-1 cell lines, respectively[1]. In addition, it has been shown to have a concentration-dependent inhibitory effect on fatty acid amide hydrolase (FAAH), an enzyme responsible for the degradation of endogenous cannabinoids in the nervous system[2].
[1] TICONA L A, COBALLES M R, POTENTE G, et al. Anti-inflammatory Potential of Macamides Isolated from Yellow Tubers of Mashua (Tropaeolum Tuberosum)[J]. Planta Medica International Open, 2020. DOI:10.1055/a-1159-4242.
[2] M ALASMARI. Inhibition of Fatty Acid Amide Hydrolase (FAAH) by Macamides.[J]. Molecular Neurobiology, 2019. DOI:10.1007/s12035-018-1115-8.
