Parathyroid hormone (PTH) is an 84 amino acid hormone involved in calcium regulation in counteraction to calcitonin. PTH regulates serum phosphate levels and vitamin D biosynthesis. N-terminal peptides of PTH are used to elicit and study a wide variety of responses in target cells.
Active fragment (1-34) of endogenous human
parathyroid hormone:
Treatment of osteoporosis in postmenopausal
women and men at increased risk of fractures
Treatment of corticosteroid-induced osteoporosis
Teriparatide, parathyroid hormone (1–34), is the only anabolic agent available in the United States for the treatment of postmenopausal osteoporosis. Side effects that human should report to doctor or health care professional as soon as possible:
allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
blood in the urine; pain in the lower back or side; pain when urinating
signs and symptoms of low blood pressure like dizziness; feeling faint or lightheaded, falls; unusually weak or tired
signs and symptoms of increased calcium like nausea; vomiting; constipation; low energy; or muscle weakness
No metabolism or excretion studies have been performed.
Peripheral metabolism of PTH is believed to occur by
non-specific enzymatic mechanisms in the liver followed
by excretion via the kidneys. The 24-hour urine excretion
of calcium was reduced by a clinically unimportant
amount (15%).
