≥26.3 mg/mL in EtOH; insoluble in H2O; ≥38.8 mg/mL in DMSO
form
solid
pka
6.55±0.42(Predicted)
Usage And Synthesis
Uses
VUF 10166 is a 5-HT3 receptor antagonist. VUF 10166 exhibits partial agonist activity at 5-HT3A receptors at higher concentrations. VUF 10166 is also histamine H4 receptor antagonist.
Biological Activity
vuf10166 is a novel, potent and competitive antagonist for 5-ht3a receptor with ki of 0.04 nm, its affinity at 5-ht3ab receptor is significantly lower.
