VU-29

Product NameVU-29
CAS890764-36-0
MFC22H16N4O3
MW384.39
EINECS
MOL File890764-36-0.mol

Chemical Properties

Melting point	221-223℃
Boiling point	545.0±45.0 °C(Predicted)
Density	1.30
storage temp.	Store at RT
solubility	Soluble to 100 mM in DMSO
form	Powder
pka	11.17±0.70(Predicted)
color	Light yellow to yellow

Usage And Synthesis

Uses

DPAP is a potent, postive allosteric, potentiator at mGluR-5.

in vivo

VU-29 (500 nM) potentiates DHPG induced increases in phosphoinositide (PI) hydrolysis in rat hippocampal slices. VU-29 potentiates threshold TBS-induced long term potentiation (LTP) in rat hippocampal CA1 region. VU-29 (1 μM) potentiates chemically induced mGluR-long term depression (LTD) in area CA1 of the rat hippocampus. VU-29 (1 μM) potentiates stimulus-induced NMDA receptor-independent LTD^[1].

IC 50

rat mGluR5: 9 nM (EC₅₀); rat mGluR1: 557 nM (EC₅₀); rat mGluR2: 1.5 μM (EC₅₀); hmGluR4: 154 nM (EC₅₀); rat mGluR5: 224 nM (Ki)