ChemicalBook > Product Catalog > Biochemical Engineering > Inhibitors > Metabolism > PPAR agonists > Pioglitazone
Pioglitazone Chemical Properties
- Melting point:183-184 C
- Boiling point:575.4±45.0 °C(Predicted)
- Density 1.260±0.06 g/cm3(Predicted)
- form White to off-white solid.
Pioglitazone Usage And Synthesis
- Usesantihyperlipidemic, HMGCoA reductase inhibitor
- DefinitionChEBI: A member of the class of thiazolidenediones that is 1,3-thiazolidine-2,4-dione substituted by a benzyl group at position 5 which in turn is substituted by a 2-(5-ethylpyridin-2-yl)ethoxy group at position 4 of the phenyl ring. It exhibits hypoglycemic acti ity.
- IndicationsPioglitazone is approved for use as monotherapy and in conjunction with metformin, sulfonylureas, and insulin. It is taken once a day with or without food. Though pioglitazone may also cause a small increase in low-density lipoprotein concentrations, there is usually a modest decrease in triglyceride levels, but it unclear whether this has any clinical significance or persists in the long term.
- brand nameActos (Takeda).
- General DescriptionPioglitazone, (±)-5-[[4-[2-(5-ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-2,4-thiazolidinedione (Actos),is an odorless, white, crystalline powder that must be convertedto a salt such as its hydrochloride before it will haveany water solubility. Although the molecule contains one chiralcenter, the compound is used as the racemic mixture. Thisis primarily a result of the in vivo interconversion of the twoenantiomers. Thus, there are no differences in the pharmacologicalactivity of the two enantiomers.
Pioglitazone Preparation Products And Raw materials
- PINEPOLLEN 5-Hydroxy Pioglitazone EPEBT(INTERMEDIATE OF PIOGLITAZONE HCL) 5-Desethyl 5-Carboxy Pioglitazone Pioglitazone N-Oxide Hydroxy Pioglitazone-D5 (Major) (M-IV)(Mixture of diastereomers) N-Hydroxy Pioglitazone-deuterated (M-IV) (Mixture of diastereomers) 5-(4-(2-(5-Ethylpyridin-2-yl)ethoxy)benzylidene)thiazolidine-2,4-dione N-[Ethyl-(2-pyridyl-5-ethyl) Pioglitazone(Pioglitazone Impurity),4-[2-(5-Ethyl-2-pyridinyl)ethoxy]benzenepropanoic Acid Ethyl Ester(Pioglitazone Impurity) PIOGLITAZONE-D3 PIOGLITAZONE-D4, KETONE Pioglitazone, hydroxyl M-II,Hydroxy Pioglitazone (M-II) (Mixture of Diastereomers) 5-[4-[2-(5-ETHYL-2-PYRIDYL) ETHOXY] BENZYL}-2-IMINO-4-THIAZOLIDINONE, PIOGLITAZONE INETRMEDIATE PG-4 4-METHOXYTOLUENE-2,3,5,6-D4 5-Ethyl-2-pyridineethanol Keto PioglitazoneDiscontinued see product # K200600,Keto Pioglitazone,Keto-Pioglitazone (M-III),Pioglitazone, ketone Pioglitazone Pioglitazone, hydroxy M-IV,Hydroxy Pioglitazone (M-IV)
- Company Name:Shanghai ACT chemical Limited Gold
- Company Name:J & K SCIENTIFIC LTD.
- Tel:010-82848833- ;010-82848833-
- Company Name:Pure Chemistry Scientific Inc.
- Tel:001-857-928-2050 or 1-888-588-9418
- Company Name:LGM Pharma
- Company Name:Nanjing Chemlin Chemical Co., Ltd