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Pioglitazone

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Pioglitazone Basic information
Pioglitazone Chemical Properties
  • Melting point:183-184 C
  • Boiling point:575.4±45.0 °C(Predicted)
  • Density 1.260±0.06 g/cm3(Predicted)
  • pka6.35±0.50(Predicted)
  • form White to off-white solid.
Safety Information
MSDS
Pioglitazone Usage And Synthesis
  • Usesantihyperlipidemic, HMGCoA reductase inhibitor
  • DefinitionChEBI: A member of the class of thiazolidenediones that is 1,3-thiazolidine-2,4-dione substituted by a benzyl group at position 5 which in turn is substituted by a 2-(5-ethylpyridin-2-yl)ethoxy group at position 4 of the phenyl ring. It exhibits hypoglycemic acti ity.
  • IndicationsPioglitazone is approved for use as monotherapy and in conjunction with metformin, sulfonylureas, and insulin. It is taken once a day with or without food. Though pioglitazone may also cause a small increase in low-density lipoprotein concentrations, there is usually a modest decrease in triglyceride levels, but it unclear whether this has any clinical significance or persists in the long term.
  • brand nameActos (Takeda).
  • General DescriptionPioglitazone, (±)-5-[[4-[2-(5-ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-2,4-thiazolidinedione (Actos),is an odorless, white, crystalline powder that must be convertedto a salt such as its hydrochloride before it will haveany water solubility. Although the molecule contains one chiralcenter, the compound is used as the racemic mixture. Thisis primarily a result of the in vivo interconversion of the twoenantiomers. Thus, there are no differences in the pharmacologicalactivity of the two enantiomers.
Pioglitazone Preparation Products And Raw materials
Pioglitazone(111025-46-8)Related Product Information
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  • Company Name:Shanghai ACT chemical Limited Gold
  • Tel:21-59904146-
  • Email:sales@actchemical.com
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  • Company Name:J & K SCIENTIFIC LTD.
  • Tel:010-82848833- ;010-82848833-
  • Email:jkinfo@jkchemical.com;market6@jkchemical.com
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  • Company Name:Pure Chemistry Scientific Inc.
  • Tel:001-857-928-2050 or 1-888-588-9418
  • Email:sales@chemreagents.com
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  • Company Name:LGM Pharma
  • Tel:1-(800)-881-8210
  • Email:inquiries@lgmpharma.com
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  • Company Name:Nanjing Chemlin Chemical Co., Ltd
  • Tel:025-83697070
  • Email:sales@chemlin.com.cn
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