利马前列素
利马前列素 性质
| 熔点 | 97-100° |
|---|---|
| 沸点 | 550.6±50.0 °C(Predicted) |
| 密度 | 1.118 |
| 储存条件 | -20°C |
| 溶解度 | 在DMF中可溶 |
| 形态 | 结晶 |
| 酸度系数(pKa) | 4.78±0.10(Predicted) |
| 颜色 | 白色至米白色 |
| InChIKey | OJZYRQPMEIEQFC-UAWLTFRCSA-N |
| SMILES | C(O)(=O)/C=C/CCCC[C@H]1C(=O)C[C@@H](O)[C@@H]1/C=C/[C@@H](O)C[C@@H](C)CCCC |
利马前列素 用途与合成方法
Limaprost inhibits the IL-1-mediated induction of nerve growth factor (NGF) in a concentration-dependent manner with an IC 50 value of 70.9 nM human IVD cells.
Limaprost (OP1206) given orally at more than 100 mg/kg relieves Argipressin-induced ST depression of rat electrocardiogram (ECG).
Intra-coronary injection of Limaprost (OP1206; 1-100 ng/kg) in dogs results in a remarkable increase of coronary blood flow without any influence on heart rate, blood pressure, myocardial oxygen consumption and redox potential.
Resistance in both large and small vessels of dog coronary artery is decreased by intravenous injection of Limaprost (OP1206; 1-3 mg/kg).
Platelet aggregation, adhesiveness, bleeding time, and thrombocytopenia induced by ADP and collagen infusion in guinea-pigs are inhibited by oral administration of Limaprost (OP1206) at the same doses or doses less than those relieving Argipressin-induced ST depression of ECG.
安全信息
| 危险品标志 | T |
|---|---|
| 危险类别码 | 25 |
| 安全说明 | 36/37/39-45 |
| 危险品运输编号 | UN 2811 6.1/PG 2 |
| WGK Germany | 3 |
| RTECS号 | UK8362500 |
| 存储类别 | 6.1A - 可燃，急性毒性物质（类别1和类别2） 剧毒的危险物质 |
| 危险性类别 | 急性毒性 类别2 经口 |
利马前列素 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026-09-15 | HY-B0683 | 利马前列素 | 74397-12-9 | 2mg | 1200 |
| 2026-09-15 | HY-B0683 | 利马前列素 | 74397-12-9 | 5mg | 2381 |
