Anisomelic acid: a cembrane-type macrocyclic diterpenoid possesses both anticancer and antiviral activity
Anisomelic acid (AA) is one of the principle bioactive compounds isolated from the plant Anisomeles malabarica. It is a membrane-type macrocyclic diterpenoid that presents potent cytotoxicity. It possesses both anticancer and antiviral activity. Researchers have studied the mode of action of AA-mediated apoptosis, indicating that AA inhibits the expression of the E6 and E7 viral proteins. In addition, AA is also effective in inducing apoptosis in other HPV-positive cervical cancer cells, with a high degree of specificity to HPV-positive cells and insignificant effects on HPV-negative cells[1-2].
[1] Rajendran Senthilkumar. “Synthesis and Evaluation of Anisomelic acid-like Compounds for the Treatment of HPV-Mediated Carcinomas.” Scientific Reports (2019): 20295.
[2] Christo Paul Preethy. “Analysis of the Cytotoxic Potential of Anisomelic Acid Isolated from Anisomeles malabarica.” Scientia Pharmaceutica 81 2 (2013): 559–66.
