3-Bromo-4-methoxybenzaldehyde

• Asymmetric synthesis of a novel β-hydroxy-α-amino acid derivative, via Mukaiyama aldol reaction.
• Synthesis of 2-(3-bromo-4-methoxyphenyl)-5-fluorobenzothiazole.
• Preparation of 5-[(Z)-2-(3-bromo-4-methoxyphenyl)vinyl]-1,2-3-trimethoxybenzene.
• Total synthesis of engelhardione.
• Starting reagent for the synthesis of (2E)-3-(3-bromo-4-methoxyphenyl)-1-(4-methylphenyl)prop-2-en-1-one.

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34841-06-0

(2) In a 4000 mL three-necked flask protected by passing nitrogen, 740.7 g of 3-bromo-4-hydroxybenzaldehyde, 2000 g of N,N-dimethylformamide and 558.0 g of potassium carbonate were added. The reaction system was cooled to 0~5 °C and 775 g of iodomethane was added dropwise slowly. After the dropwise addition, the reaction solution was concentrated and poured into ice water to precipitate a solid. After filtration and recrystallization, a white crystalline product 3-bromo-4-methoxybenzaldehyde was obtained as 752.7 g, yield 95.0%.