Glucose-dependent Insulinotropic Peptide (22-51) (human) (trifluoroacetate salt)

Glucose-dependent insulinotropic peptide (GIP) (22-51) is a pro-atherogenic 30-amino acid peptide corresponding to residues 22-51 of the GIP precursor protein proGIP that has been found in human plasma.1 It induces IκB-α degradation and NF-κB nuclear translocation in macrophage-differentiated THP-1 cells and isolated human aortic endothelial cells when used at a concentration of 1 µM. In vivo, GIP (22-51) increases atherosclerotic lesion area and plaque formation in ApoE-/- mice.WARNING This product is not for human or veterinary use.

[1] TSUGUTO MASAKI. GIP_HUMAN[22-51] is a new proatherogenic peptide identified by native plasma peptidomics.[J]. ACS Applied Electronic Materials, 2021: 14470. DOI: 10.1038/s41598-021-93862-w