Glucose-dependent Insulinotropic Polypeptide (1-42) (porcine) (trifluoroacetate salt)

Glucose-dependent Insulinotropic Polypeptide (GIP) (1-42) is an endogenous 42-amino acid peptide incretin hormone that induces insulin secretion.1,2 It is expressed in intestinal neuroendocrine K cells and the submandibular gland and is released into circulation postprandially. GIP (1-42) inhibits histamine, pentagastrin, and insulin-induced gastric acid and pepsin secretion, increases glucose-induced insulin release, and stimulates gastric emptying in rats.3WARNING This product is not for human or veterinary use.

[1] HANS-CHRISTOPH FEHMANN  Burkhard G. Characterization of GIP(1–30) and GIP(1–42) as stimulators of proinsulin gene transcription[J]. Peptides, 1995, 16 6: Pages 1149-1152. DOI: 10.1016/0196-9781(95)00090-7
[2] ALEXANDROS P. SISKOS. Simultaneous Absolute Quantification of the Glucose-Dependent Insulinotropic Polypeptides GIP1−42 and GIP3−42 in Mouse Plasma by LC/ESI-MS/MS: Preclinical Evaluation of DP-IV Inhibitors[J]. Journal of Proteome Research, 2009, 8 7: 3487-3496. DOI: 10.1021/pr900155h
[3] WOJCIECH J. ROSSOWSKI. Reduced gastric acid inhibitory effect of a pGIP(1–30)NH2 fragment with potent pancreatic amylase inhibitory activity[J]. Regulatory Peptides, 1992, 39 1: Pages 9-17. DOI: 10.1016/0167-0115(92)90003-d