ChemicalBook Product Catalog Biochemical Engineering Amino Acids and Derivatives Amino alcohol derivative CREATINE PHOSPHATE DISODIUM SALT HEXAHYDRATE

CREATINE PHOSPHATE DISODIUM SALT HEXAHYDRATE

Product NameCREATINE PHOSPHATE DISODIUM SALT HEXAHYDRATE
CAS19333-65-4
MFC4H20N3Na2O11P
MW363.17
EINECS213-074-6
MOL File19333-65-4.mol

Chemical Properties

storage temp.	-20°C
solubility	PBS (pH 7.2): 10 mg/ml
form	White crystalline
color	White to off-white
Water Solubility	water: 50mg/mL, clear, colorless
InChI	1S/C4H10N3O5P.2Na.H2O/c1-7(2-3(8)9)4(5)6-13(10,11)12;;;/h2H2,1H3,(H,8,9)(H4,5,6,10,11,12);;;1H2/q;2*+1;/p-2
InChIKey	KZVYPOKBYRXZKS-UHFFFAOYSA-L
SMILES	O.[Na+].[Na+].CN(CC(O)=O)C(=N)NP([O-])([O-])=O
CAS DataBase Reference	19333-65-4(CAS DataBase Reference)

Safety Information

WGK Germany	3
Storage Class	11 - Combustible Solids

MSDS

Provider	Language
SigmaAldrich	English

Usage And Synthesis

Chemical Properties

Crystalline

Uses

Phosphocreatine disodium salt hydrate has been used:

as a component: of Xenopus buffer (XB) buffer to remove the membrane-bound proteins
of M5⁺buffer to perform polarized total internal reflection fluorescence (polTIRF) experiments
of ATP regenerating system for 7-nitro-2-1,3-benzoxadiazol-4-yl phospholipid(NBD-PL) translocation assay

General Description

Creatine phosphate is a high-energy phosphate compound that stores energy from mitochondria whenever sufficient amounts of ATP are present. When ATP levels are low, energy from phosphocreatine is transferred to ADP molecules, which are quickly converted to ATP. It is often a component of ATP-generating systems.

Biochem/physiol Actions

Phosphocreatine is widely known for its quickest form of regeneration using enzyme creatine kinase. It functions as a temporal energy buffer. Phosphocreatine is present in muscle tissues and plays a major role in maintaining energy homeostasis in muscle cells.

in vivo

Non-salt form:
Phosphocreatine (200 mg/kg, i.p., once every other day, 7 weeks) not only alleviates oxidative stress and myocardial apoptosis, but also rescues myocardial necroptosis in DOX-induced cardiotoxicity of rat^[2].
Phosphocreatine (20-40 mg/kg, i.v., daily, 6 weeks) has a protective effect on the kidney tissues against diabetic nephropathy in SD (Sprague Dawley) rats^[4].

Animal Model:	Male Sprague Dawley (SD) rats, i.p., normal saline, 3 times; i.p., DOX 2 mg/kg, 7 times; i.p., normal saline, 3 times ^[2]
Dosage:	200 mg/kg
Administration:	i.p., once every other day, 7 weeks
Result:	Improved the heart function abnormality. Lowered myocardial apoptosis. Recovered the expression of Nrf2, SOD, FoxO3a and diminished C-Casp3, Bax/Bcl2 in the myocardial tissue of rats. Markedly improved myocardial necroptosis, as indicated by decreasing expression of RIP3 and CaMKII. Increased expression level of TAK1.

Animal Model:	Male Sprague Dawley (SD) rats, i.p., 70 mg/kg (STZ(Streptozotocin) (HY-13753)), daily, 6 weeks ^[4]
Dosage:	20, 40 mg/kg
Administration:	i.p., daily, 6 weeks
Result:	Reduced hyperglycemia compared with STZ (Streptozotocin) (HY-13753) -treated rats. Increased the weight of rats gradually compared with STZ (Streptozotocin) (HY-13753) group. Decreased kidney weight index (kidney weight/body weight). Decreased MDA level and increased of GSH and SOD levels compared with STZ group. Decreased the apoptotic rate compared with MGO-treated groups.

IC 50

Human Endogenous Metabolite

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