Terretonin is a fungal terpenoid isolated from Aspergillus terreus. The complete biosynthetic pathway of terretonin includes: cytochrome P450 Trt6 catalyzes the oxidation of terrenoid to obtain an unstable intermediate; then it is catalyzed by isomerase Trt14 and processed by non-heme iron-dependent dioxygenase Trt7 to complete the biosynthesis of terretonin[1].
ChEBI: A tetracyclic meroterpenoid that is isolated from Aspergillus terreus.
[1] Matsuda Y, et al. Uncovering the unusual D-ring construction in terretonin biosynthesis by collaboration of a multifunctional cytochrome P450 and a unique isomerase[J]. Journal of the American Chemical Society, 2015, 137(9): 3393-3401.
