MIDAGLIZOLE HYDROCHLORIDE
英文名称:2-[2-(4,5-dihydro-1H-imidazol-2-yl)-1-phenyl-ethyl]pyridine dihydrochl oride
CAS号:79689-25-1
分子式:C16H19Cl2N3
分子量:0
EINECS号:
Mol文件:79689-25-1.mol
![MIDAGLIZOLE HYDROCHLORIDE 结构式](https://img.chemicalbook.com/CAS/GIF/79689-25-1.gif)
MIDAGLIZOLE HYDROCHLORIDE 用途与合成方法
Midaglizole hydrochloride (DG5128) 是有效的 α2-肾上腺素受体拮抗剂。Midaglizole hydrochloride (DG5128) 对 α2-肾上腺素能受体的亲和力 (pKi= 6.28) 比 α1-肾上腺素能受体高 7.4 倍。
pKi :6.28 (α2-adrenoceptor)
Midaglizole (DG-5128) at concentrations up to 10 μM inhibits [ 3 H]clonidine binding more effectively than it doed [ 3 H]prazosin binding in rat cerebral cortex membranes. The mode of inhibition is homogeneous and consistent with the law of simple mass action. The EC 50 values for stimulation of insulin release from rat islets and the MIN6 β-cell line induced by Midaglizole are 200 nM and 24 μM, respectively. The IC 50 values for K ATP current inhibition induced by Midaglizole are 3.8 μM and 4.4 uM for Kir6.2 and Kir6.2/SUR1 , respectively.
Midaglizole (3 and 30 mg/kg, i.v.) increases blood pressure in pithed rats.
MIDAGLIZOLE HYDROCHLORIDE 价格(试剂级)
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
---|---|---|---|---|---|
2024-04-30 | HY-U00165 | 1 mg | 1760 | ||
2024-04-30 | HY-U00165 | MIDAGLIZOLE HYDROCHLORIDE | 5 mg | 4400 |
MIDAGLIZOLE HYDROCHLORIDE供应商 更多
成都超九八生物科技有限公司
联系电话:13348960310 13348960310
产品介绍:
英文名称:Midaglizole hydrochloride
CAS:79689-25-1
纯度:98%
包装信息:5mg;10mg;20mg;50mg;100mg;200mg
天津普西唐生物医药科技有限公司
联系电话:010-60605840 15801484223;
产品介绍:
中文名称:咪格列唑盐酸盐
英文名称:Midaglizole hydrochloride
CAS:79689-25-1
包装信息:100mg
备注: 试剂级
TargetMol中国(陶术生物)
联系电话: 4008200310
产品介绍:
中文名称:咪格列唑盐酸盐
英文名称:Midaglizole hydrochloride
CAS:79689-25-1
纯度:100%
包装信息:1 mg;1 mL;10 mg;100 mg;25 mg;5 mg;50 mg