Vatanidipine hydrochloride

Product NameVatanidipine hydrochloride
CAS133743-71-2
MFC41H42N4O6.2HCl
MW723.27
EINECS
MOL File133743-71-2.mol

Usage And Synthesis

Uses

Vatanidipine (Watanidipine) hydrochloride is an orally active dihydropyridine (DHP)-type calcium channel blocker and a useful antihypertensive agent. Vatanidipine hydrochloride shows vasodilatory effects and also suppresses noradrenaline release from sympathetic nerve endings[1][2].

Definition

ChEBI: Vatanidipine hydrochloride is a diarylmethane.

Safety Profile

A poison by ingestion, intraperitoneal, and subcutaneous routes. When heated to decomposition it emits toxic vapors of NOx.

in vivo

Vatanidipine (1-10 mg/kg, p.o.) suppresses the systolic blood pressure of spontaneously hypertensive rats^[1].

References

[1] Matsumura Y, et al. Vatanidipine hydrochloride: a new long-lasting antihypertensive agent. Expert Opin Investig Drugs. 2001 Jan;10(1):139-55. DOI:10.1517/13543784.10.1.139
[2] H Shinyama, et al. Effects of the calcium antagonist AE0047 on the development of neurological deficit and infarction after middle cerebral artery occlusion in stroke-prone spontaneously hypertensive rats. J Pharm Pharmacol. 1997 Sep;49(9):919-24. DOI:10.1111/j.2042-7158.1997.tb06136.x