Silanol, 1-cyclohexyl-1-(4-fluorophenyl)-1-[3-(1-piperidinyl)propyl]-, hydrochloride (1:1)

p-F-HHSiD (p-Fluorohexahydrosiladifenidol) hydrochloride is a selective M3 mAChR antagonist. p-F-HHSiD hydrochloride blocks Acetylcholine-mediated vasodilatation in human umbilical vein endothelial cells (HUVECs)[1][2].

mAChR3

[1] Eglen RM, et al. Interaction of p-F-HHSiD (p-Fluoro-hexahydrosila-difenidol) at muscarinic receptors in guinea-pig trachea. Naunyn Schmiedebergs Arch Pharmacol. 1990 Oct;342(4):394-9. DOI:10.1007/BF00169455
[2] He Y, et al. In utero hypoxia attenuated acetylcholine-mediated vasodilatation via CHRM3/p-NOS3 in fetal sheep MCA: role of ROS/ERK1/2. Hypertens Res. 2022 Jul;45(7):1168-1182. DOI:10.1038/s41440-022-00935-y