2-[2-(2-hydroxyethoxy)ethoxy]ethyl acrylate

Hydroxy-PEG3-acrylate is a PEG linker containing a hydroxyl group and an acrylate group. The hydroxyl group allows for further derivatization of the compound. The acrylate group enables Michael addition reactions. The hydrophilic PEG spacer increases solubility in aqueous media.

Hydroxy-PEG3-acrylate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

PEGs

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005