Furobactil,Carrion,France,1974
ChEBI: Nifurfoline is an imidazolidine-2,4-dione.
20 g of nitrofurantoin are placed in 100 cc of dimethylformamide and the
solution is heated to 75°C to 80°C. This temperature is maintained and 100 cc
of 40% formaldehyde are added, followed by 10 g of freshly distilled
morpholine. The heating is continued for one hour, the mixture cooled and
filtered and the precipitate obtained is washed with 95% alcohol. 20 g of the
desired product are obtained as yellow crystals which melt at 206°C.
