2,4-DICHLORO-5-AMINO-6-METHYLPYRIMIDINE

13162-26-0

13162-27-1

2,4-Dichloro-5-nitro-6-methylpyrimidine (860 mg) was used as a feedstock and co-dissolved with Pd/C (180 mg) in ethyl acetate (30 mL). Hydrogen was passed three times at room temperature to displace the air in the reaction system, followed by the reaction at 40 psi hydrogen pressure. Upon completion of the reaction, the Pd/C catalyst was removed by filtration to afford the yellow solid product 2,4-dichloro-5-amino-6-methylpyrimidine (500 mg) in 65.1% yield.