ChemicalBook Product Catalog Biochemical Engineering Biochemical Reagents Agonist Inhibitors 4-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-1-butanone hydrochloride

4-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-1-butanone hydrochloride

Product Name4-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-1-butanone hydrochloride
CAS1511-16-6
MFC21H24Cl2FNO2
MW412.33
EINECS689-044-5
MOL FileMol File

Chemical Properties

Melting point	226-227.5°
storage temp.	Store at -20°C
solubility	insoluble in H2O; ≥10.31 mg/mL in DMSO; ≥2.96 mg/mL in EtOH with gentle warming and ultrasonic
form	solid

Usage And Synthesis

Uses

Haloperidol Hydrochloride is the salt analogue of Haloperidol (H103700) a dopamine inverse agonist, antidyskinetic and antipsychotic agent.

Biological Activity

haloperidol hydrochloride is an antipsychotic drug that has similar actions to the antipsychotic medicine phenothiazine [1].haloperidol hydrochloride has been reported to play a role as an inverse agonist of dopamine. in addition, haloperidol hydrochloride has been found to be highlt potent neuroleptic by relieving nervous through the depression of nerve function. besides, haloperidol hydrochloride has shown about 50-fold potency than chiorpromazine, the other antipsychotic drug. haloperidol hydrochloride has shown beneficial effects in the treatment of delusions and hallucinations. these effects are mainly achieved through blockage of dopamine receptors in the mesocortex and limbic system. haloperidol hydrochloride has been revealed to prevent the effects of dopamine in the nigrostriatal pathways, which probably explains the associated side effects such as akathisia and dystonias[1].

in vivo

Haloperidol (1 mg) intra-arterially attenuates the dopamine-induced pancreatic secretion. Haloperidol (3 mg) completely inhibits the action of 10 μg of dopamine in the pancreas of the dogs^[1]. Haloperidol (10 mg/kg) as well as chlorpromazine (CPZ, 15 mg/kg) blocks mescaline-induced altered behavior within 7 to 10 minutes when injected into the mice 45 minutes after 50 mg/kg (2 μc) of mescaline. Haloperidol has no effect on mescaline disappearance^[2].

IC 50

D₂ Receptor

storage

Room temperature

References

[1] dr ananya mandal, md .haloperidol pharmacology.

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