Basic information Safety Related Supplier
ChemicalBook >  Product Catalog >  API >  Nervous system drugs >  Antipsychotics >  Duloxetine

Duloxetine

Basic information Safety Related Supplier
Duloxetine Basic information
Duloxetine Chemical Properties
Safety Information
Duloxetine Usage And Synthesis
  • UsesAntidepressant.
  • brand nameCymbalta (Lilly).
  • General DescriptionDuloxetine (Cymbalta) is a newer antidepressant. It islargely like venlafaxine, which is an SNERI (selective norepinephrinereuptake inhibitor).
  • PharmacokineticsDuloxetine appears to be fairly well absorbed after oral doses, with peak plasma levels in 6 to 10 hours and linear pharmacokinetics. The drug is extensively metabolized in the liver to active metabolites, with 72% of an oral dose primarily excreted in the urine as conjugated metabolites and up to 15% appearing in the feces.
    N-demethylation to an active metabolite (CYP2D6) and hydroxylation of the naphthyl ring (CYP1A2) at either the 4-, 5-, or 6-positions are the main metabolic pathways for duloxetine. Its metabolites are primarily excreted into the urine as glucuronide, sulfate, and O-methylated conjugation products. The major metabolites found in plasma also were found in the urine. Preclinical data for 4-hydroxyduloxetine suggests it has a similar pharmacological profile to duloxetine, with selective inhibition of SERT but less activity at the NET.
  • Clinical UseDuloxetine has been approved for the treatment of depression and diabetic peripheral neuropathic pain. It is another analogue in the line of fluoxetine-based products from Lilly, in which the phenyl and phenoxy groups of fluoxetine have been respectively replaced with the benzene isostere, thiophene, and a naphthyloxy group (previously described under fluoxetine). Duloxetine exhibits dual inhibition with high affinity for the SERTs and NETs, with a five times preferential inhibition of the SERT. Duloxetine appears to be a more potent in vitro blocker of SERTs and NETs than venlafaxine. In humans, duloxetine has a low affinity for the other neuroreceptors, suggesting low incidence of unwanted adverse effects.
Duloxetine Preparation Products And Raw materials
Duloxetine(116539-59-4)Related Product Information
DuloxetineSupplierMore
  • Company Name:3B Pharmachem (Wuhan) International Co.,Ltd.
  • Tel:18930552037 821-50328103-801
  • Email:3bsc@sina.com
  •  
  • Company Name:LGM Pharma
  • Tel:1-(800)-881-8210
  • Email:inquiries@lgmpharma.com
  •  
  • Company Name:Shanghai Longsheng chemical Co.,Ltd.
  • Tel:13585536065 021-58099652-8005
  • Email:bin.wu@shlschem.com;sales@shlschem.com
  •  
  • Company Name:China Langchem Inc.
  • Tel:0086-21-58956006,021-38701807
  • Email:sales@langchem.com
  •  
  • Company Name:Hunan Hui Bai Shi Biotechnology Co., Ltd.
  • Tel:13308453923 0731-85529965-
  • Email:3002708854@qq.com;3002778010@qq.com;3002732518@qq.com
  •