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Duloxetine

Duloxetine Structure
Duloxetine
  • CAS No.116539-59-4
  • Chemical Name:Duloxetine
  • CBNumber:CB8670379
  • Molecular Formula:C18H19NOS
  • Formula Weight:297.41
  • MOL File:116539-59-4.mol
Duloxetine Property
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

Duloxetine Chemical Properties,Usage,Production

  • Uses Antidepressant.
  • brand name Cymbalta (Lilly).
  • General Description Duloxetine (Cymbalta) is a newer antidepressant. It islargely like venlafaxine, which is an SNERI (selective norepinephrinereuptake inhibitor).
  • Pharmacokinetics Duloxetine appears to be fairly well absorbed after oral doses, with peak plasma levels in 6 to 10 hours and linear pharmacokinetics. The drug is extensively metabolized in the liver to active metabolites, with 72% of an oral dose primarily excreted in the urine as conjugated metabolites and up to 15% appearing in the feces.
    N-demethylation to an active metabolite (CYP2D6) and hydroxylation of the naphthyl ring (CYP1A2) at either the 4-, 5-, or 6-positions are the main metabolic pathways for duloxetine. Its metabolites are primarily excreted into the urine as glucuronide, sulfate, and O-methylated conjugation products. The major metabolites found in plasma also were found in the urine. Preclinical data for 4-hydroxyduloxetine suggests it has a similar pharmacological profile to duloxetine, with selective inhibition of SERT but less activity at the NET.
  • Clinical Use Duloxetine has been approved for the treatment of depression and diabetic peripheral neuropathic pain. It is another analogue in the line of fluoxetine-based products from Lilly, in which the phenyl and phenoxy groups of fluoxetine have been respectively replaced with the benzene isostere, thiophene, and a naphthyloxy group (previously described under fluoxetine). Duloxetine exhibits dual inhibition with high affinity for the SERTs and NETs, with a five times preferential inhibition of the SERT. Duloxetine appears to be a more potent in vitro blocker of SERTs and NETs than venlafaxine. In humans, duloxetine has a low affinity for the other neuroreceptors, suggesting low incidence of unwanted adverse effects.
Duloxetine Preparation Products And Raw materials
Raw materials
Preparation Products
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116539-59-4, DuloxetineRelated Search:
  • DULOXETINE
  • DULOXETINE-D3
  • (S)-DULOXETINE
  • DULOXETIN
  • (3S)-N-methyl-3-naphthalen-1-yloxy-3-thiophen-2-yl-propan-1-amine
  • N-Methyl-gama-(1-naphthalenyloxy)-2-thiophenepropanamine
  • DULOXETINE HCI
  • Duloxetine & Intermediates
  • N-methyl-3-(1-naphthalenyloxy)-3-thiophen-2-yl-1-propanamine hydrochloride
  • CS-559
  • methyl-[(3S)-3-(1-naphthyloxy)-3-(2-thienyl)propyl]amine
  • (3R)-N-methyl-3-(naphthalen-1-yloxy)-3-thiophen-2-ylpropan-1-amine
  • (S)-N-Methyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-aMine
  • Duloxetine Hcl(S)
  • Duloxetine, >=99%
  • Methyl[(3S)-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propyl]aMine
  • 116539-59-4
  • 1165399-59-4
  • C18H18ONSHCL
  • C18N19NOS
  • C18H19NOS
  • API
  • ACTIVE PHARMACEUTICAL INGREDIENTS