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Olmesartan medoxomil intermediate.
Olmesartan medoxomil analog as angiotensin II antagonist.
N-1 Trityl Olmesartan Medoxomil (Olmesartan EP Impurity D) is an olmesartan medoxomil intermediate.
This describes steps for preparing a trityl-protected intermediate in olmesartan medoxomil synthesis:
1. An imidazole ester derivative is alkylated with a trityl-protected biphenyltetrazole bromide in acetone with KCO/phase-transfer catalyst. Work-up gives an intermediate.
2. This intermediate is further alkylated with a side-chain bromide in the presence of acetone/KCO/KI. Treatment with toluene/methanol precipitates trityl olmesartan ester.
