2,5-DIBROMOPHENOL

3638-73-1

28165-52-8

General procedure for the synthesis of 2,5-dibromophenol from 2,5-dibromoaniline: Sodium nitrite (65.2 mmol) was added in batches to a solution of trifluoroacetic acid (80 mL) containing 2,5-dibromoaniline (55.8 mmol) at 0 °C. Subsequently, the resulting solution was slowly added to a boiling solution of 50% sulfuric acid (120 mL) containing sodium sulfate (10 g) and the reaction mixture was kept at reflux for 1 hour. Upon completion of the reaction, the product was steam distilled and the distillate was extracted using dichloromethane (2 x 200 mL). The organic layers were combined, dried over sodium sulfate and concentrated to give 2,5-dibromophenol as a yellow solid in 41% yield.