ACTH (6-24) (human, mouse, rat, porcine, bovine, ovine) (trifluoroacetate salt)

ACTH (6-24) is a peptide fragment of adrenocorticotropic hormone (ACTH; Item No. 24257), a peptide hormone found in the brain that is involved in the biological stress response.1,2 ACTH (6-24) is a competitive inhibitor of steroidogenesis induced by ACTH (1-39) and ACTH (5-24) with mean Kd values of 13.4 and 3.4 nM, respectively.3 It also inhibits corticosterone production and cAMP accumulation induced by human parathyroid hormone (1-34) (Item No. 24985) when used at a concentration of 100 nM.4WARNING This product is not for human or veterinary use.

[1] JEAN-LUC FAUCHÈRE  Claudia P. Synthesis and Biological Activity of Four Adrenocorticotropin-(1-24)-tetracosapeptide Analogues with N-Terminal Deletions of Four to Seven Amino-Acid Residues†[J]. Helvetica Chimica Acta, 1978, 61 3: 1186-1192. DOI: 10.1002/hlca.19780610334
[2] F L STRAND. Non-corticotropic ACTH peptides modulate nerve development and regeneration.[J]. Reviews in the Neurosciences, 1993, 4 4: 321-363. DOI: 10.1515/revneuro.1993.4.4.321
[3] A F BRISTOW. Effects of ACTH (corticotropin) analogues on steroidogenesis and cyclic AMP in rat adrenocortical cells. Evidence for two different steroidogenically responsive receptors.[J]. Biochemical Journal, 1980, 186 2: 599-603. DOI: 10.1042/bj1860599
[4] B RAFFERTY. Corticosteroidogenesis and adenosine 3’, 5’- monophosphate production by the amino-terminal (1-34) fragment of human parathyroid hormone in rat adrenocortical cells.[J]. Endocrinology, 1983, 113 3: 1036-1042. DOI: 10.1210/endo-113-3-1036