ACTH (1-10) (human, mouse, rat, porcine, bovine, ovine) (trifluoroacetate salt)

Adrenocorticotropic hormone (ACTH) (1-10) is an N-terminal peptide fragment of ACTH, a peptide hormone produced by the anterior pituitary gland that is involved in the biological stress response.1,2 The amino acid sequence of ACTH (1-10) is common to ACTH and α-melanocyte stimulating hormone.3 ACTH (1-10) is an agonist of melanocortin receptor 3 (MC3R) and MC4R (EC50s = 2.6 and 200 nM, respectively, for the recombinant human receptors) and increases adenylate cyclase activity in HEK293 cells expressing human recombinant MC1R (EC50 = 25 nM).3,4 It inhibits extinction of the conditioned avoidance response rats in shuttle-box and pole-jumping tests when administered at doses of 10 and greater than 20 μg, respectively.1,5 Intracerebroventricular injection of ACTH (1-10) reduces the incidence and severity of cold-restraint stress-induced gastric lesions in rats.6WARNING This product is not for human or veterinary use.

[1] B. BOHUS  D. de W. Inhibitory and Facilitatory Effect of Two Related Peptides on Extinction of Avoidance Behavior[J]. Science, 1966, 153 3733. DOI: 10.1126/science.153.3733.318
[2] F L STRAND. Non-corticotropic ACTH peptides modulate nerve development and regeneration.[J]. Reviews in the Neurosciences, 1993, 4 4: 321-363. DOI: 10.1515/revneuro.1993.4.4.321
[3] H MIWA. Structural determinants of the melanocortin peptides required for activation of melanocortin-3 and melanocortin-4 receptors.[J]. Journal of Pharmacology and Experimental Therapeutics, 1995, 273 1: 367-372.
[4] MARINA TSATMALIA. Skin POMC Peptides: Their Binding Affinities and Activation of the Human MC1 Receptor[J]. Annals of the New York Academy of Sciences, 2006, 885 1: 466-469. DOI: 10.1111/j.1749-6632.1999.tb08714.x
[5] T B V WIMERSMA GREIDANUS  D de W. Effects of systemic and intracerebral administration of two opposite acting ACTH-related peptides on extinction of conditioned avoidance behavior.[J]. Neuroendocrinology, 1971, 7 5: 291-301. DOI: 10.1159/000121977
[6] DANIEL E. HERNANDEZ. Brain acth prevents stress gastric lesions in rats[J]. Brain Research Bulletin, 1990, 25 4: Pages 605-607. DOI: 10.1016/0361-9230(90)90119-k