AC187 trifluoroacetate salt

AC 187 is a synthetic peptide that corresponds to amino acids 8-32 of salmon calcitonin (sCT; Item No. 24410) and an antagonist of calcitonin and amylin receptors.1 It inhibits human calcitonin-induced cAMP accumulation in COS-7 cells expressing the human calcitonin receptor or the human amylin receptors AMY1a or AMY3a (pKBs = 7.15, 7.3, and 7.37, respectively). AC 187 (10 µM) protects against apoptosis induced by amyloid-β (1-42) (Aβ42; Item No. 20574) in primary rat basal forebrain neurons.2 Intrathecal administration of AC 187 (50 µl of a 3 µg/µl solution) increases the paw withdrawal threshold in the von Frey test in a rat model of chronic peripheral neuropathic pain induced by spared nerve injury.3 AC 187 (10 µg/kg) reverses sCT-induced decreases in food intake in food-deprived rats.4WARNING This product is not for human or veterinary use.

[1] DEBBIE L HAY. Pharmacological discrimination of calcitonin receptor: receptor activity-modifying protein complexes.[J]. Molecular Pharmacology, 2005, 67 5: 1655-1665. DOI: 10.1124/mol.104.008615
[2] JACK H JHAMANDAS  David M. Antagonist of the amylin receptor blocks beta-amyloid toxicity in rat cholinergic basal forebrain neurons.[J]. Journal of Neuroscience, 2004, 24 24: 5579-5584. DOI: 10.1523/jneurosci.1051-04.2004
[3] LÍGIA SOFIA ALMEIDA. Amylin, a peptide expressed by nociceptors, modulates chronic neuropathic pain[J]. European Journal of Pain, 2018, 23 4: 784-799. DOI: 10.1002/ejp.1347
[4] T.A LUTZ . Amylin receptors mediate the anorectic action of salmon calcitonin (sCT)[J]. Peptides, 2000, 21 2: Pages 233-238. DOI: 10.1016/s0196-9781(99)00208-9