Ac-AAVALLPAVLLALLAP-IETD-CHO (trifluoroacetate salt)

Ac-AAVALLPAVLLALLAP-IETD-CHO is a composite of Ac-IETD-CHO (Item No. 27100), a peptide inhibitor of caspase-8, and a cell-permeable hydrophobic sequence derived from K-FGF.1,2 It is an inhibitor of both caspase-8 and granzyme B.1,3,4 It prevents death of SKOV3 ovarian carcinoma cells transfected with Survivin and granzyme B-induced apoptosis (SAGA) when used at a concentration of 20 µM.4WARNING This product is not for human or veterinary use.

[1] M GARCIA-CALVO. Inhibition of human caspases by peptide-based and macromolecular inhibitors.[J]. The Journal of Biological Chemistry, 1998, 273 49: 32608-32613. DOI: 10.1074/jbc.273.49.32608
[2] Y Z LIN. Inhibition of nuclear translocation of transcription factor NF-kappa B by a synthetic peptide containing a cell membrane-permeable motif and nuclear localization sequence.[J]. The Journal of Biological Chemistry, 1995, 270 24: 14255-14258. DOI: 10.1074/jbc.270.24.14255
[3] RITU RAJ KUMAR S A. Advances in Theranostic Nanomedicine: Integrating Diagnosis and Therapy for Precision Cancer Treatment.[J]. Current stem cell research & therapy, 2025. DOI: 10.2174/011574888x362719250603073728
[4] HUGO CALDAS. Survivin and Granzyme B-induced apoptosis, a novel anticancer therapy.[J]. Molecular Cancer Therapeutics, 2006, 5 3: 693-703. DOI: 10.1158/1535-7163.mct-05-0423