Ac-IETD-CHO (trifluoroacetate salt)

Ac-IETD-CHO is an inhibitor of caspase-8 (IC50 = 5 nM).1 It inhibits fluticasone propionate-induced increases in apoptosis in peripheral blood T-cells isolated from patients with asthma when used at a concentration 60 μM.2 Ac-IETD-CHO (10 mg/kg) inhibits increases in hepatic caspase-3 activity, DNA fragmentation, cytosolic cytochrome c levels, and proteolytic processing of caspase-3, -8, and -9 proenzymes in a mouse model of Fas-induced apoptosis and liver failure.3WARNING This product is not for human or veterinary use.

[1] GARY K. SMITH . Expression, Preparation, and High-Throughput Screening of Caspase-8: Discovery of Redox-Based and Steroid Diacid Inhibition[J]. Archives of biochemistry and biophysics, 2002, 399 2: Pages 195-205. DOI: 10.1006/abbi.2002.2757
[2] ELISABETTA PACE MD , PHD. Synergistic effects of fluticasone propionate and salmeterol on in vitro T-cell activation and apoptosis in asthma[J]. Journal of Allergy and Clinical Immunology, 2004, 114 5: Pages 1216-1223. DOI: 10.1016/j.jaci.2004.07.052
[3] M L BAJT. Protection against Fas receptor-mediated apoptosis in hepatocytes and nonparenchymal cells by a caspase-8 inhibitor in vivo: evidence for a postmitochondrial processing of caspase-8.[J]. Toxicological Sciences, 2000, 58 1: 109-117. DOI: 10.1093/toxsci/58.1.109