Ac-(D-Arg)-CEH-(D-Phe)-RWC-NH2 (trifluoroacetate salt)

Ac-(D-Arg)-CEH-(D-Phe)-RWC-NH2 is a cyclic peptide and an agonist of melanocortin receptor 4 (MC4R).1 It induces cAMP release in HEK293 cells expressing human MC4R (EC50 = 0.28 nM). Ac-(D-Arg)-CEH-(D-Phe)-RWC-NH2 is selective for MC4R over MC1R, MC3R, and MC5R (Kis = 0.55, 16.78, 56.79, and >500 nM, respectively). It decreases food intake and body weight in a rat model of diet-induced obesity when administered at doses of 0.075 or 0.299 µmol/kg.WARNING This product is not for human or veterinary use.

[1] JOHN P. MAYER. Discovery of a β-MSH-Derived MC-4R Selective Agonist§[J]. Journal of Medicinal Chemistry, 2005, 48 9: 3095-3098. DOI: 10.1021/jm0501432