(+)-氯前列烯醇
(+)-氯前列烯醇 性质
| 沸点 | 628.0±55.0 °C(Predicted) |
|---|---|
| 密度 | 1.321 |
| 储存条件 | Store at -20°C |
| 溶解度 | DMF：>100 mg/ml（来自氟前列醇）； DMSO：>100 mg/ml（来自氟前列醇；乙醇：>100 mg/ml（来自氟前列醇）；PBS pH 7.2：>16 mg/ml（来自氟前列醇） |
| 酸度系数(pKa) | 4.76±0.10(Predicted) |
| 形态 | 油状物 |
| 颜色 | 无色至浅黄 |
(+)-氯前列烯醇 用途与合成方法
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PGF 2α
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D-Cloprostenol and PGF2 alpha are equipotent, about 150 times more potent than dl-cloprostenol (P < 0.05) and approximately 280 times more potent than PGE1 in inhibiting [ 3 H]PGF2 alpha binding to corpus luteum cell membranes. However, d-cloprostenol and PGF2 alpha are about 10 times more potent than dl-cloprostenol and approximately 95 times more potent than PGE1 in myometrial cell membranes.
D-cloprostenol (15 g per head) is the lowest dose that consistently achieves abortion; D-cloprostenol causes mild adverse effects including salivation, defecation and hyperventilation in bitches weighing less than 10 kg. Intra-vesicle administration of a single low dose of d-cloprostenol is a safe and successful technique to induce abortion in the bitch.
