FRAXIN

Slightly soluble in cold water, soluble in hot water and hot ethanol, practically insoluble in ether. Derived from the dried bark of the ash tree of the family Mulleinaceae, the pointed leaf ash or the persistent column ash

food and beverages

ChEBI: Fraxin is a beta-D-glucoside that is fraxetin attached to a beta-D-glucopyranosyl group at position 8 via a glycosidic linkage. It is a natural product isolated from the leaves of Fraxinus excelsior and exhibits potent hepatoprotective effects in vitro and in vivo. It has a role as a plant metabolite, an anti-inflammatory agent and a hepatoprotective agent. It is a beta-D-glucoside, a hydroxycoumarin and an aromatic ether. It is functionally related to a fraxetin.

A method for extracting high-purity Qinpi methanin and Qinpi glucoside from Qinpi, characterized in that it comprises the steps of:

(1) using methanol or water conventional method to obtain Qinpi extract containing Qinpi methylin, Qinpi glycoside and other different mass concentrations;

(2) prepare a biphasic system and separate to obtain the upper and lower phase solutions of the biphasic phase, and dissolve the Qinpi extract repeatedly with the upper phase solution until the Qinpi extract does not contain Qinpi methylin and Qinpi glucoside;

(3) after centrifugation or filtration of the above solution containing qinpi methylin and qinpi glycoside, add 1 to 3 times the amount of the above solution to the lower phase solution, full extraction, until the proportion of solid impurities in the upper phase is no longer significantly reduced, the separation of the upper phase solution obtained, concentrated to obtain the solution containing mainly qinpi methylin and qinpi glycoside;

(4) using conventional means to remove salts and fat-soluble impurity components, concentration, crystallization to obtain high-purity Qinpi methylin and Qinpi glucoside.