(-)-Hydroxycitric acid calcium salt

Product Name(-)-Hydroxycitric acid calcium salt
CAS27750-10-3
MFC6H8O8
MW208.12
EINECS
MOL File27750-10-3.mol

Chemical Properties

Boiling point	393.3±42.0 °C(Predicted)
Density	1.947±0.06 g/cm3(Predicted)
pka	2.90±0.28(Predicted)
form	Solid
color	White to off-white

Usage And Synthesis

Uses

(-)-Hydroxycitric acid (Garcinia acid) is the principal acid of fruit rinds of Garcinia cambogia. (-)-Hydroxycitric acid is a potent and competitive and orally active inhibitor of ATP citrate lyase. (-)-Hydroxycitric acid suppresses the fatty acid synthesis, lipogenesis, food intake, and induced weight loss[1][2].

Definition

ChEBI: Garcinia acid is a carbonyl compound.

in vivo

(-)-Hydroxycitric acid (1.0 mg/kg embryos, injection) reduces lipid droplets accumulation, triglyceride content, lipogenesis factors mRNA level and increases lipolysis factors mRNA expression in chicken embryos^[3].
(-)-Hydroxycitric acid (p.o., once) shows a LD50 of greater than 5000 mg/kg in fasted male and female Albino rats^[5].
(-)-Hydroxycitric acid (1000-3000 mg/kg diet for 8 weeks) reduces body weight gain, increases feed conversion ratio, and promotes protein synthesis in rats^[6].

References

[1] B. S. Jena, et al. Chemistry and Biochemistry of ()-Hydroxycitric Acid from Garcinia. J. Agric. Food Chem. 2002, 50, 1, 10-22.
[2] Hayamizu K, et al. Effects of garcinia cambogia (Hydroxycitric Acid) on visceral fat accumulation: a double-blind, randomized, placebo-controlled trial. Curr Ther Res Clin Exp. 2003 Sep;64(8):551-67. DOI:10.1016/j.curtheres.2003.08.006
[3] Li S, et al. (-)-Hydroxycitric Acid Influenced Fat Metabolism via Modulating of Glucose-6-phosphate Isomerase Expression in Chicken Embryos. J Agric Food Chem. 2019 Jul 3;67(26):7336-7347. DOI:10.1021/acs.jafc.9b02330
[4] Li L, et al. (-)-Hydroxycitric Acid Reduced Lipid Droplets Accumulation Via Decreasing Acetyl-Coa Supply and Accelerating Energy Metabolism in Cultured Primary Chicken Hepatocytes. Cell Physiol Biochem. 2017;43(2):812-831. DOI:10.1159/000481564
[5] Ohia SE, et al. Safety and mechanism of appetite suppression by a novel hydroxycitric acid extract (HCA-SX). Mol Cell Biochem. 2002 Sep;238(1-2):89-103. DOI:10.1023/a:1019911205672
[6] Han N, et al. (-)-Hydroxycitric Acid Nourishes Protein Synthesis via Altering Metabolic Directions of Amino Acids in Male Rats. Phytother Res. 2016 Aug;30(8):1316-29. DOI:10.1002/ptr.5630

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