消旋型二氟甲基腈盐酸盐
消旋型二氟甲基腈盐酸盐 性质
| 熔点 | 138 °C |
|---|---|
| 沸点 | 347.0±42.0 °C(Predicted) |
| 密度 | 1.1800 (estimate) |
| 储存条件 | Store at 0°C |
| 溶解度 | H2O: >10 mg/mL, 可溶 |
| 酸度系数(pKa) | 1.22±0.44(Predicted) |
| 形态 | 固体 |
| 颜色 | 白色 |
| InChI | 1S/C6H12F2N2O2.ClH.H2O/c7-4(8)6(10,5(11)12)2-1-3-9;;/h4H,1-3,9-10H2,(H,11,12);1H;1H2 |
| InChIKey | FJPAMFNRCFEGSD-UHFFFAOYSA-N |
| SMILES | O.Cl.NCCCC(N)(C(F)F)C(O)=O |
消旋型二氟甲基腈盐酸盐 用途与合成方法
Eflornithine is the only new molecule registered for the treatment of human African trypanosomiasis over the last 50 years. It is the drug used mainly as a back-up for melarsoprol refractory Trypanosoma brucei gambiense cases. In subjects with excessive, unwanted facial hair, eflornithine 15% cream is superior to placebo in reducing hair growth. After 24 weeks' treatment, 58% of eflornithine and 34% of placebo subjects have at least some improvement in facial hirsutism. The hair growth inhibitory activity of eflornithine is significantly enhanced when the eflornithine cream is applied onto a mouse skin area pretreated with microneedles. Treatment of coarctation hypertensive rats with eflornithine results in a normalization of the contractile intensity to KCI and norepinephrine and relaxations to acetylcholine by 14 days of hypertension.
