(S)-(+)-1-Aminoindan

clear yellow liquid

(S)-1-Aminoindane is the S-enantiomer of 1-Aminoindane; the metabolite of the monoamine oxidase-B inhibitor Rasagiline (R126000).

Add 1.00 g (4.80 mmol) of di-(S-(+)-1-aminoindan)- D-tartrate to a 250 mL flask, 40 mL of water, heated with stirring to dissolve completely, cooled to room temperature, added 20% NaOH solution dropwise, adjusted the PH to 10, and extracted with 40 mL each time. Trichloromethane was extracted three times, the organic phases were combined, dried with anhydrous magnesium sulfate for 20 min, filtered and concentrated to obtain 0.97 g of light yellow liquid (S)-(+) . -1-aminoindan, ee value (HPLC method) was 79.6%, the yield was 97.0%.