m-PEG8-succinimidyl carbonate

m-PEG8-succinimidyl carbonate is a PEG linker containing a succinimidyl carbonate group. Succinimidyl carbonate group is a good leaving group and commonly reacts with amine nucleophiles. The hydrophilic PEG linker increases the water solubility properties of the compound.

m-PEG8-succinimidyl carbonate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

PEGs; Alkyl/ether

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005