m-PEG4-succinimidyl carbonate is a PEG linker containing a succinumidyl carbonate group. The succinimidyl carbonate group is a good leaving group and commonly reacts with amine nucleophiles.
Uses
m-PEG4-O-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
IC 50
PEGs
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
