Propargyl-PEG4-sulfonic acid

Product NamePropargyl-PEG4-sulfonic acid
CAS1817735-29-7
MFC11H20O7S
MW296.34
EINECS
MOL File1817735-29-7.mol

Chemical Properties

Density	1.245±0.06 g/cm3(Predicted)
solubility	Soluble in Water, DMSO, DCM, DMF
pka	1.34±0.50(Predicted)
form	Solid
color	White to off-white

Usage And Synthesis

Description

Propargyl-PEG4-sulfonic acid is heterobifunction reagent that can reacts with azide compounds or biomolecules via copper catalyzed Click Chemistry reactions.

Uses

Propargyl-PEG4-sulfonic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Propargyl-PEG4-sulfonic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005