8-NITROTRYPTANTHRIN
8-NITROTRYPTANTHRIN 性质
熔点 | >250 °C |
---|---|
沸点 | 551.2±52.0 °C(Predicted) |
密度 | 1.67±0.1 g/cm3(Predicted) |
储存条件 | Sealed in dry,Store in freezer, under -20°C |
溶解度 | DMSO:4.2(最大浓度 mg/mL);14.32(最大浓度 mM) |
形态 | 结晶固体 |
酸度系数(pKa) | -7.55±0.20(Predicted) |
颜色 | 白色至米白色 |
8-NITROTRYPTANTHRIN 用途与合成方法
rhIDO2 1.8 μM (IC 50 ) |
rhIDO2 0.97 μM (Ki) |
The typtanthrin derivative GNF-PF-3777 (8-Nitrotryptanthrin; Compound 5i) is found to be a potent hIDO2 inhibitor with superior efficiency far better than that of the most frequently-used inhibitor L-1-MT. The IC 50 values show that all nine tryptanthrin compounds display hIDO2 inhibitory activities, GNF-PF-3777 demonstrates much stronger inhibition (1.87 μM) than both L-1-MT (82.53 μM) and D-1-MT (262.75 μM). GNF-PF-3777 exhibits significant antitrypanosomal activity with EC 50 of 0.82 μM. GNF-PF-3777 (8-Nitrotryptanthrin) has a microplate Alamar Blue assay (MABA) minimum inhibitory concentration (MIC) value of 0.032 μg/mL. GNF-PF-3777 also has a LORA MIC value of 2.4 μg/mL, while the majority of analogues lack LORA activity.
8-NITROTRYPTANTHRIN 价格(试剂级)
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
---|---|---|---|---|---|
2024-11-08 | HY-100687 | 8-NITROTRYPTANTHRIN | 77603-42-0 | 1mg | 900 |
2024-11-08 | HY-100687 | 8-NITROTRYPTANTHRIN | 77603-42-0 | 5mg | 2160 |