8-NITROTRYPTANTHRIN
8-NITROTRYPTANTHRIN 性质
| 熔点 | >250 °C |
|---|---|
| 沸点 | 551.2±52.0 °C(Predicted) |
| 密度 | 1.67±0.1 g/cm3(Predicted) |
| 储存条件 | Sealed in dry,Store in freezer, under -20°C |
| 溶解度 | DMSO：4.2（最大浓度 mg/mL）；14.32（最大浓度 mM） |
| 形态 | 结晶固体 |
| 酸度系数(pKa) | -7.55±0.20(Predicted) |
8-NITROTRYPTANTHRIN 用途与合成方法
|
rhIDO2 1.8 μM (IC 50 ) |
rhIDO2 0.97 μM (Ki) |
The typtanthrin derivative GNF-PF-3777 (8-Nitrotryptanthrin; Compound 5i) is found to be a potent hIDO2 inhibitor with superior efficiency far better than that of the most frequently-used inhibitor L-1-MT. The IC 50 values show that all nine tryptanthrin compounds display hIDO2 inhibitory activities, GNF-PF-3777 demonstrates much stronger inhibition (1.87 μM) than both L-1-MT (82.53 μM) and D-1-MT (262.75 μM). GNF-PF-3777 exhibits significant antitrypanosomal activity with EC 50 of 0.82 μM. GNF-PF-3777 (8-Nitrotryptanthrin) has a microplate Alamar Blue assay (MABA) minimum inhibitory concentration (MIC) value of 0.032 μg/mL. GNF-PF-3777 also has a LORA MIC value of 2.4 μg/mL, while the majority of analogues lack LORA activity.
8-NITROTRYPTANTHRIN 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-04-30 | HY-100687 | 8-NITROTRYPTANTHRIN | 77603-42-0 | 5mg | 2500 |
| 2024-04-30 | HY-100687 | 8-NITROTRYPTANTHRIN | 77603-42-0 | 10mg | 3800 |
