Acetazolamide sodium

Acetazolamide sodium is a carbonic anhydrase (CA) IX inhibitor with an IC50 of 30 nM for hCA IX. Acetazolamide sodium has diuretic, antihypertensive and anti-gonococcal activities[1][4][5][6].

ChEBI: Acetazolamide sodium is an organic sodium salt. It contains an acetazolamide and an acetazolamide(1-).

Diamox (Duramed).

ACETAZOLAMIDE SODIUM SALT SODIUMACETAZOLAMIDE

CA Ⅸ

[1] Bayat Mokhtari R, et al. Acetazolamide potentiates the anti-tumor potential of HDACi, MS-275, in neuroblastoma. BMC Cancer. 2017 Feb 24;17(1):156. DOI:10.1186/s12885-017-3126-7
[2] Hou Z, et al. Dual-tail approach to discovery of novel carbonic anhydrase IX inhibitors by simultaneously matching the hydrophobic and hydrophilic halves of the active site. Eur J Med Chem. 2017 May 26;132:1-10. DOI:10.1016/j.ejmech.2017.03.023
[3] Gao H, et al. Combined treatment with acetazolamide and cisplatin enhances chemosensitivity in laryngeal carcinoma Hep-2 cells. Oncol Lett. 2018 Jun;15(6):9299-9306. DOI:10.3892/ol.2018.8529
[4] Kassamali R, et al. Acetazolamide: a forgotten diuretic agent. Cardiol Rev. 2011 Nov-Dec;19(6):276-8. DOI:10.1097/CRD.0b013e31822b4939
[5] Jabeen E, et al. Interaction of antihypertensive acetazolamide with nonsteroidal anti-inflammatory drugs. J Photochem Photobiol B. 2013 Aug 5;125:155-63. DOI:10.1016/j.jphotobiol.2013.06.002
[6] Abutaleb NS, et al. In vivo efficacy of acetazolamide in a mouse model of Neisseria gonorrhoeae infection. Microb Pathog. 2022 Mar;164:105454. DOI:10.1016/j.micpath.2022.105454