N-Boc-PEG6-alcohol

Product NameN-Boc-PEG6-alcohol
CAS331242-61-6
MFC17H35NO8
MW381.46
EINECS
MOL File331242-61-6.mol

Chemical Properties

Boiling point	487.1±45.0 °C(Predicted)
Density	1.087±0.06 g/cm3(Predicted)
solubility	Soluble in DMSO, DCM, DMF
pka	12.23±0.46(Predicted)
form	Viscous Liquid
color	Colorless to light yellow

Safety Information

HS Code

2924190090

Usage And Synthesis

Description

N-Boc-PEG6-alcohol is a PEG linker containing a Boc protected amine group and a terminal hydroxyl group. The Boc protecting group can be removed under acidic conditions. The hydroxyl group can react to further derivatize the compound. The hydrophilic PEG linker increases the water solubility of the compound.

Uses

N-Boc-PEG6-alcohol is a PROTAC bridge that belongs to the PEG class and the Alkyl/ether class. N-Boc-PEG6-alcohol can be used to synthesize a series of PROTAC molecules from Chemicalbook. N-Boc-PEG6-alcohol is a cleavable ADC bridge for the synthesis of antibody drug conjugates (ADCs).

in vitro

PROTACscontaintwodifferentligandsconnectedbyalinker;oneisaandforanE3ubiquitinligaseandtheotherisforthetargetprotein.PROTACsexploittheintracelChemicalbooklularubiquitin-proteasomesystemtoselectivelydegradetargetproteins.ADCsarecomprisedofanantibodytowhichisattachedanADCcytotoxinthroughanADClinker.