t-Boc-N-amido-PEG9-amine is a monodisperse PEG reagent containing an amino group and Boc-protected amino group. The hydrophilic PEG spacer increases solubility in aqueous media. The Boc group can be deprotected under mild acidic conditions to form the free amine.
Boc-amido-PEG9-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Our highly purified mono-protected homobifunctional polyethylene glycols display oligomer purities of more than 90%. This extremely narrow distribution of oligomers ensures homogeneous products in many applications such as conjugation reactions or introduction of solubilizing units or spacers.
reagent type: cross-linking reagent
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:
10.1016/j.ebiom.2018.09.005
