36.6 g (45.0 mmol) of heptane glycol distearate, 150 mL of CH₂Cl₂, and 0.677 g of 10% palladium/carbon were loaded into a high-pressure Monel alloy bomb with a glass insert. Hydrogenolysis was carried out at room temperature under 50 atm of H₂ for 48 hours. The reaction was filtered off and the catalyst (which could be reused) was washed with CH₂Cl₂. The filtrate was concentrated to give a mixture of (triphenylmethane) and oil. The mixture was dissolved in boiling methanol, and most of the triphenylmethane was crystallized by cooling the solution to 0°C. The mixture was filtered and the filtrate was washed six times with hexane to remove trace amounts of triphenylmethane, giving hexaethylene glycol.
Figure 1 Synthetic route of hexaethylene glycol
Hexaethylene glycol is a polymer consisting of ethylene glycol monomers and two terminal hydroxyl groups. The PEG chain increases the water solubility of a compound in aqueous media. Increasing the number of ethylene glycol units within the entire chain improves the solubility properties of the PEG linker.
viscous colourless liquid
Substrate employed in the synthesis of binaphthol-based macrocyclic ethers using intramolecular oxidative coupling with CuCl(OH)-TMEDA.1
Hexaethylene glycol exhibits antioxidant, antimicrobial and anti-cancer properties. It also shows potential application as functional hydraulic fluids. It is used as a surfactant building block as well as used in biological sample preparation. Further, it is employed in the synthesis of binaphthol-based macrocyclic ethers using intramolecular oxidative coupling with CuCl(OH).
Hexaethylene Glycol is part of a leaf extract (Murdannia Bracteata) which exhibits antioxidant, antimicrobial and anti-cancer properties. It also shows potential application as functional hydraulic fl
uids.
ChEBI: Hexaethylene glycol is a poly(ethylene glycol).
