Amino-PEG9-t-butyl ester

Product NameAmino-PEG9-t-butyl ester
CAS1818294-44-8
MFC25H51NO11
MW541.67
EINECS
MOL File1818294-44-8.mol

Chemical Properties

Boiling point	576.2±45.0 °C(Predicted)
Density	1.071±0.06 g/cm3(Predicted)
storage temp.	Storage temp. 2-8°C
solubility	Soluble in Water, DMSO, DCM, DMF
form	Liquid
pka	8.74±0.10(Predicted)
color	Colorless to light yellow

Usage And Synthesis

Description

Amino-PEG9-t-butyl ester is a PEG molecule with an amino group and a t-butyl protected carboxyl group (tBoc). The hydrophilic PEG spacer increases solubility in aqueous media. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The t-butyl protected carboxyl group can be deprotected under acidic conditions.

Uses

Amino-PEG9-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs; Alkyl/ether

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005