Amino-PEG6-t-butyl ester is a PEG reagent containing an amino NH2 group with a t-butyl protected carboxyl group (Boc). The hydrophilic PEG spacer increases solubility in aqueous media. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The t-butyl protected carboxyl group can be deprotected under acidic conditions.
This heterobifunctional, PEGylated crosslinker features an amino group at one end and t-butyl-protected carboxyl group at the other, which can be deprotected with acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. Amino-PEG6-t-butyl ester can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC
molecules) for
targeted protein degradation.
H2N-PEG6-tBu (CAS 1286281-32-0) is a high-purity, PEG-based PROTAC linker suitable for the synthesis of PROTACs. It has a molecular weight of 409.51 and appears as a colourless to pale yellow viscous liquid or a low-melting-point waxy solid at room temperature. Synonyms include Amino-PEG6-t-butyl ester, NH₂-PEG6-CH₂CH₂COO-tBu, NH₂-PEG6-Boc, H₂N-PEG6-CH₂CH₂COO-tBu and Amino-PEG6-COO-tBu, amongst others.
reagent type: cross-linking reagent
PEGs; Alkyl/ether; Non-cleavable Linker
