Pharmaceutical Applications
4-fluoro-2-Methoxy-5-nitroaniline is a specialized intermediate in
pharmaceutical production. It's used for synthesizing more complex
chemicals, often integral parts of final drug molecules.
4-FLUORO-2-METHOXYANILINE(551 mg, 3.90 mmol) is dissolved in dichloromethane (39.0 mL), concentrated sulfuric acid (1.85 mL) is added dropwise with stirring under ice-cooling, and then concentrated nitric acid (267 μL, 5.85 mmol) is added dropwise. After stirring for 3 hours under ice-cooling, saturated aqueous sodium bicarbonate was added until pH 8 was reached. After washing with saturated aqueous sodium bicarbonate solution, washing with saturated brine, the organic layer was dried over sodium sulfate and evaporated under reduced pressure to obtain 675 mg of the 4-fluoro-2-Methoxy-5-nitroaniline (yield 93%).
[1] Journal of Heterocyclic Chemistry, 2017, vol. 54, # 5, p. 2898 - 2901
[2] Patent: WO2017/120429, 2017, A1. Location in patent: Page/Page column 340
[3] Patent: CN105524068, 2016, A. Location in patent: Paragraph 0181; 0183
[4] Patent: CN105884695, 2016, A. Location in patent: Paragraph 0233; 0234; 0235
[5] Patent: US2017/8889, 2017, A1. Location in patent: Paragraph 0135; 0138
